R&D
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Job Title: Distinguished Scientist, Head of Investigative Toxicology US

Location: Cambridge, MA

About the Job

Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.

The incumbent will be responsible for oversight and management of the Investigative Toxicology laboratory in the US and execution of strategies to strengthen and evolve liver and immune-related safety assessment, incorporating microphysiological systems (MPS) where needed. This candidate will ensure that Sanofi employs an evolving, innovative strategy for assessing liver and immune-related risks that align with regulatory guidance and scientific practice. This role will involve direct supervision of laboratory colleagues and/or lab heads working transversally with colleagues within PCS and across Sanofi sites, and external vendors, to provide project support and drive collaboration. This role will also be responsible for leading efforts and devising strategies to manage safety issues relevant to molecules at all stages of the Research and Development portfolio, and providing subject matter expertise related to liver safety.  Participation in external consortia and representing Sanofi at relevant scientific venues is also an important component of this role.

Terms of employment

Occasional domestic and international travel to Sanofi Research and Development sites (e.g Paris, France; Frankfurt, Germany) and scientific meetings.  Availability to start in 1Q2026.

What makes this position unique?

The candidate will be part of an established highly effective Investigative Toxicology group at Sanofi and have opportunity to manage a laboratory and help shape and guide research in the toxicology field, particularly with respect to liver safety assessment and application of MPS models. There is also the opportunity to learn and grow in the immunotoxicology area. There is tremendous opportunity for innovation within the role, and the global scope will provide the candidate with a rich, diverse work experience.

About Sanofi:
We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

Main Responsibilities

• Supervise and manage colleagues in the US Investigative Toxicology group, including performance assessment and development planning; provide mentorship and guidance to support career growth.

• Provide technical expertise in model and assay development relevant for both liver and the immune system, ensuring sufficient scientific rigor. Oversee appropriate qualification/validation plans and testing strategies, particularly for the MPS models, to ensure robust performance.  

• Define strategies and mechanistic experiments to understand safety issues; lead and manage execution of such strategies. Work collaboratively and transversally to ensure such strategies meet project and regulatory requirements; author reports to support inclusion of results in white papers or regulatory submissions as needed.

• Provide subject matter expertise on liver safety assessment and lead liver translational safety initiatives.

• Provide leadership regarding MPS models and in vitro new alternative models (NAMs) within Preclinical Safety and the broader Sanofi Research and Development organization.

• Participate in external consortia or working groups to stay abreast of liver safety knowledge and trends within the scientific community, regulatory environment, and the pharmaceutical industry. Represent Sanofi interests, maintaining high ethical and scientific standards.

• Author external presentations and manuscripts to contribute to scientific advancement of the toxicology field.

About You

Requirements & Qualifications

• A PhD in toxicology, pharmacology, biology, engineering, or equivalent scientific discipline required, with a minimum of 10 years of relevant experience in a pharmaceutical or biopharmaceutical setting.

• Knowledge and experience in liver toxicology and MPS models is required. Excellent management and leadership skills are essential.

• The ability to collaborate effectively with other scientists, subject matter experts and project teams is also essential.

• Experience working with immune models and immunotoxicology is a plus. Established record of scientific contribution in peer-reviewed journals and scientific symposiums.

• Excellent verbal and written communication skills are required.

Why Choose Us?

• Bring the miracles of science to life alongside a supportive, future-focused team.

• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

• Be part of an active, innovative scientific group

• Have diverse opportunities to collaborate on a global scale

• Be highly recognized for successes

• Receive excellent benefits and compensation

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.

Pursue Progress. Discovery Extraordinary.

Werde Teil von Sanofi und starte mit uns in eine neue Ära der Wissenschaft – wo dein persönliches Wachstum genauso wegweisend ist wie unsere Arbeit. Wir investieren in dich, damit du weiterkommst, schneller denkst und Dinge möglich machst, die vorher undenkbar waren. Du wirst Grenzen verschieben, Gewohntes hinterfragen und smarte Lösungen entwickeln, die direkt bei den Menschen ankommen, für die wir da sind. Bereit, die Wunder der Wissenschaft zu jagen und Leben zu verbessern? Dann lass uns gemeinsam Großes bewegen – und das Außergewöhnliche entdecken.

Bei Sanofi stehen allen die gleichen Chancen offen – unabhängig von Herkunft, Hautfarbe, Religion, Geschlecht, Nationalität, sexueller Orientierung, Alter, Staatsangehörigkeit, Familienstand, Behinderung, Geschlechtsidentität, Veteranenstatus oder anderen gesetzlich geschützten Merkmalen.