R&D
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Job Title: Principal Scientist, Muscle and Neuromuscular Research

About the Job

Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.

We are seeking a highly motivated Principal Scientist to drive the expansion of our muscle and neuromuscular research pipeline through both internal discovery and external innovation. The successful candidate will possess deep expertise in muscle biology, ranging from normal muscle physiology to genetic cardiac, skeletal, and neuromuscular diseases

This individual will contribute by proposing new ideas and driving the advancement of pipeline programs. The candidate is expected to collaborate with academic and industry partners to identify novel targets, disease mechanisms, and therapeutic approaches. In parallel, they will build and maintain relationships with key opinion leaders to access disease models, patient samples, and translational resources that accelerate biomarker discovery and de-risk later-stage research programs.

The position offers the opportunity to work in a highly collaborative environment and to mentor or manage a team of junior scientists.

About Sanofi:
We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

Main Responsibilities:

• Initiate and lead pipeline programs in a modality agnostic manner (biologics, oligonucleotides, small molecules, genomic medicines), including hands on work in the lab

• Landscape novel mechanisms and target discovery in the external space and balance with internal efforts to drive strategic direction and decisions within neuromuscular pipeline  

• Engage and strengthen KoL network to set up collaborations for early and late-stage research bringing in colleagues across research as needed

• Work closely with and across project teams to advance rare muscle programs through early engagement with Translational Medicine Unit to build/strengthen biomarker strategies

• Maintain close relationship with counterparts in Clinical, Medical, and Business Development organizations to support life cycle management as well as expansion of neuromuscular pipeline

• Contribute to strategic initiatives, prepare high quality presentations and communications for senior leadership and contribute to publications and regulatory filings as needed

About You

Basic Qualifications:

• Earned Ph.D. or equivalent advanced degree in molecular biology, cellular biology, or related discipline PLUS at least 5 years research experience in biopharmaceutical or academic setting

• Experience in muscle biology and neuromuscular research

• Experience in translational research and drug development

• Track record of significant contribution to research projects and scientific publications

Preferred Qualifications:

• Program leadership experience in the industry setting

• Strong understanding of emerging science, leading therapeutic approaches and competitive landscapes for neuromuscular disorders

• Experience with broad range of cell-based and animal models of muscle/neuromuscular disorders and cardiomyopthathies and relevant functional readouts

• Experience with computational biology and implementing a broad range of ‘omics approaches, including subsequent data mining/analysis

• Experience managing studies at CROs

• Familiarity with wide range of therapeutic modalities including biologics, small molecules, oligonucleotides, and/or genomic medicines

• The candidate is expected to have a strong network of research and clinician colleagues to leverage for collaboration and insight

• Experience drafting regulatory documents to support IND or CTA applications with agencies like the FDA and EMA

Skills and competencies:

• Ability to weigh and integrate inputs and opinions from broad range of stakeholders with diverse backgrounds

• Ability to capture and distill complex data, concepts, and information into clear, well-articulated messages to guide and drive decision-making

• Ability to multi-task and adapt to rapidly changing priorities and deadlines

• Excellent critical thinking, analytical, and problem-solving skills

• Excellent written and oral communication skills, with the ability to communicate effectively in a multi-disciplinary teams as well as to senior leadership

• Strong interpersonal skills, with the ability to build excellent working relationships

Why Choose Us?

• Bring the miracles of science to life alongside a supportive, future-focused team.

• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.

Pursue Progress. Discovery Extraordinary.

Werde Teil von Sanofi und starte mit uns in eine neue Ära der Wissenschaft – wo dein persönliches Wachstum genauso wegweisend ist wie unsere Arbeit. Wir investieren in dich, damit du weiterkommst, schneller denkst und Dinge möglich machst, die vorher undenkbar waren. Du wirst Grenzen verschieben, Gewohntes hinterfragen und smarte Lösungen entwickeln, die direkt bei den Menschen ankommen, für die wir da sind. Bereit, die Wunder der Wissenschaft zu jagen und Leben zu verbessern? Dann lass uns gemeinsam Großes bewegen – und das Außergewöhnliche entdecken.

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