
General Medicines
Where bold ideas and groundbreaking science shape
the future
of care
Portfolio Strategy Operations & Management Lead
At a glance
With us, you’ll break new ground across a growing and diverse portfolio – from established medicines that millions rely on to pioneering breakthroughs in immunology and chronic disease care. Imagine the scale: your work will help deliver treatments to people around the world who live with diabetes, cardiovascular disease, and complications arising from transplant.
Fueled by groundbreaking advances in technology, we are accelerating innovation and expanding access faster than ever. If you’re ready to push boundaries, embrace the power of AI and digital tools, and shape the future of healthcare, this is where your ambition meets impact.
Job Title: Portfolio Strategy Operations & Management Lead
Location: Cambridge, MA
About the job
Organizational context
Global E.D.G.E.’s (Emerging Disruptive Growth Exploration) vision is to enable an open, democratized, person-centered, tech enabled health ecosystem that
Place people, not companies, at the center their care, and in control of their data and participate in value creation
Deliver integrated first- and third-party experiences enabling to improve patient outcomes and lower costs
Connect patients and loved ones to raise the standard of care and support
In alignment with that vision, Global E.D.G.E. Portfolio Strategy & Corporate Develop (E.D.G.E. PS+CD) team is empowered to
Portfolio Strategy | Drive, design and manage a portfolio of digital healthcare use cases across the globe
Corporate Development | Identify, evaluate, and structure digital health investments to realize such a portfolio
Key dimensions of the role
Sanofi’s mission is to chase the miracles of science to improve people’s lives. Sanofi is a company that's on the rise. We're expanding in multiple directions, across borders and, most of all, in the way we think. At Sanofi, we're building a team of brilliant individuals to drive the success of a new E.D.G.E. business to transform healthcare for all. People are the most critical ingredient to our success.
Sanofi’s E.D.G.E. Team conducts cutting-edge research in the health care space and incubates data-driven digital solutions which aim to improve patients’ health outcomes, clinicians’ experience, and reduce health care costs. We are actively incubating multiple projects to improve the lives of patients globally, and we are seeking the best and the brightest to join this journey and change healthcare for all. The E.D.G.E. Portfolio consists of multiple strategically-prioritized uses case applications, and each use case application can be characterized by the following decision dimensions: 1) geography, 2) product, 3) target users, 4) commercial or monetization model, and 5) implementation plan.
This role is positioned within the E.D.G.E. PS+CD team, and will have five mandates:
Drive geographic decisions with Global Markets teams and Regional Commercial Leads
Coalesce the decision dimensions for each use case application
Develop and evangelize E.D.G.E. narrative
Co-develop executable roadmap with Global E.D.G.E. LT and other GenMed teams and mobilize Sanofi resources to execute against the roadmap
Support operational management (eg, P&L, forecasting) across E.D.G.E. offices
Main Responsibilities:
Global E.D.G.E. Portfolio Management Lead undertakes a critical role in bringing all decision dimensions of use case applications and managing the overarching portfolio. To do so, the role requires organized management of internal stakeholders globally, and they are listed in the responsibilities below.
Primary responsibilities include:
Collaboratively drive geographic decisions
Coordinate and drive geographic decisions with Global Markets teams, E.D.G.E. Regional Commercial Leads
Lead efforts to define & size opportunities to expand our global digital health ambition clearly understanding both potential agnostic and local market value contribution
Coalesce the decision dimensions into cohesive use case application
Support the design, development, and maintenance of E.D.G.E. portfolio strategy in coordination with the Global Head of Digital Healthcare Portfolio Strategy & Corporate Dev and General Medicines E.D.G.E. leadership
With support from the E.D.G.E. PS+CD team, coalesce all dimensions of individual use cases (ie, geography, product, commercial model and implementation model) into a cohesive and operationally-sensitive roadmap
Clearly translate investment parameters, alongside E.D.G.E. LT, Digital, and Corporate Development Strategy Lead
Develop narrative of and evangelize E.D.G.E. use cases
Align on prioritized use cases with Global Markets (ie, Key, Innovate-to-Grow, Foundations), Corporate Communications & Affairs, Talent, Medical, and Finance
Co-lead E.D.G.E. narratives with GenMed Corporate Communications and Affairs Lead
Maintain a working knowledge and be considered an internal expert related to evolving market externalities, such as competitive dynamics, market consolidations, legal/regulatory changes in the digital health sector, etc.
Build and execute against roadmap
With Portfolio Implementation Models Lead, bring E.D.G.E. LT together to translate each use cases into an executable roadmap
Empower Portfolio Operations Manager to mobilize optimal resources across the organization to execute against the roadmap
Co-manage resource requirements across Global E.D.G.E., alongside E.D.G.E. LT and Corporate Development Strategy Lead
Additional responsibilities include:
Grow into a next-gen leader in portfolio management
Support development and alignment of Underserved Pop Strategy
Support finance, commercial leads, and product teams in developing financial models that clearly articulate the value to Sanofi shareholders
Diligently collect and manage resources and budget across E.D.G.E. offices
Help triage, solve, ad hoc, implementation challenges on a global basis
Gain deep familiarity of the healthcare systems in the chosen markets, to inform strategic choices with the Affiliates
Support agile ways of working initiatives globally and regionally
About you
Requirements:
Domain experience
- 5+ years of experience with Digital / Virtual Healthcare Care market & dynamics
- 5+ years of experience with life sciences industry
- 5+ years professional experience in investments & / or management consulting
Functional and organizational experience
- Managed global projects in product dev, trial operations, or commercialization
- Financial management, forecasting, or investment management
- Negotiations experience
- Working in or supporting complex matrix organization
- Addressing and collaborating with diverse mix of functional and market experience
Geographic experience
- Experience collaborating with teams from multiple countries
- A keen ability to unite diverse perspectives to work toward a shared vision. Being able to work across borders and time zones.
Why Choose Us?
Bring the miracles of science to life alongside a supportive, future-focused team.
Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.
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Why work with us
- Do the never done before. We push the boundaries of what’s possible: expanding access, accelerating innovation, and finding new ways to improve everyday health for millions.
- Drive the transformation. We’re leading the shift to AI-powered healthcare, using digital tools to reinvent how medicines are developed, manufactured, and delivered worldwide.
- Deliver at scale. Our reach is unmatched—we bring trusted treatments to millions worldwide, ensuring broad access and real-world impact at every stage of care.
- Make an impact that matters. From tackling global health challenges to advancing sustainable, inclusive healthcare, everything we do is driven by purpose.
Who ignites your potential?
For Sam, it was her mom—teaching her to listen, push boundaries, and put patients first. At Sanofi, we know your inspiration drives your impact. Bring your passion, and together, we’ll chase the miracles of science.

"Each disease, each country, each person brings opportunities that challenge us to push the boundaries, to think of better ways to look at healthcare and pioneer new possibilities."

Olivier Charmeil
Executive Vice President, General Medicines
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