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Job Title:  Scientist, Retinal Degeneration

Location: Cambridge, MA

About the Job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress. 

Sanofi is seeking a highly motivated scientist to conduct preclinical drug discovery research for retinal diseases, including age-related macular degeneration and glaucoma. As a Scientist in the Retinal Degeneration group within Ophthalmology Research, you will design and execute studies to validate therapeutic strategies and discover promising drug candidates. The successful candidate will work collaboratively in matrixed, cross-functional teams to generate high-quality and comprehensive data packages to nominate and advance therapeutic candidates toward clinical development. This position offers the exciting opportunity to make significant contributions to the future of ophthalmology therapeutics and bring transformative vision-preserving treatments to patients around the world.

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?

Main Responsibilities:

• Design, execute, and document translational research studies to validate therapeutic targets and discover preclinical drug candidates

• Develop and optimize molecular, biochemical, and cellular assays to assess disease processes, target activity, and biomarkers in models of retinal disease and degeneration

• Perform experiments using genetic, biologic, and small molecule perturbations to validate targets, evaluate therapeutic strategies, and assess the pharmacology and efficacy preclinical candidates

• Analyze and interpret experimental data to support target prioritization, preclinical candidate selection, and go/no-go decisions

• Actively contribute to interdisciplinary research projects in a highly collaborative and matrixed manner

• Prepare high-quality presentations and documentation to support project deliverables, publications, patent filings, and regulatory filings

• Effectively communicate findings internally and externally through presentation and publication

About You

Basic Qualifications:

• Earned Bachelor’s degree plus minimum 6 years of relevant experience in an academic or biopharmaceutical setting or Master’s Degree plus minimum 3 years relevant experience in an academic or biopharmaceutical setting

• Research experience in ocular cell biology (e.g., RPE, RGC) or disease-relevant processes (e.g., cell death, metabolic and oxidative stress, lipid metabolism, tissue remodeling, barrier function, inflammatory signaling)

• Demonstrated experience in translational research or preclinical drug development (in vitro experience highly preferred)

• Broad experience with molecular, cellular, and biochemical methods and assay development

• Cell culture experience, including work with primary cells, iPSC-derived cells, tissue explants, or cell models relevant to ocular biology

• Experience with genetic or pharmacologic approaches to assess gene and protein function, signaling pathway activity, and/or cellular processes

• Experience preparing high-quality documents including experimental protocols, SOPs, technical reports, and presentations

• Track record of contributions to research projects and scientific publications

Preferred Qualifications:

• Experience analyzing data using computational and statistical tools (e.g., R, Python)

• Experience in translational or preclinical drug development for retinal diseases

• Experience evaluating target engagement and efficacy of preclinical candidates

• Experience developing and conducting high-throughput assays

• Experience with cell-based models of retinal disease and degeneration, including primary and iPSC-derived cells

• Experience with live-cell and high-content imaging and analyses

Skills and competencies:

• Ability to work independently as well as part of cross-functional teams in a highly collaborative and matrixed environment

• Ability to multi-task and adapt to rapidly changing priorities and deadlines

• Strong critical thinking, analytical, and problem-solving skills

• Strong written and oral communication skills, with the ability to communicate effectively in a multidisciplinary team

• Strong interpersonal skills, with the ability to build excellent working relationships

• Exceptional organizational and time-management skills, lab notebook practices, and attention to detail

Why Choose Us?

• Bring the miracles of science to life alongside a supportive, future-focused team.

• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.

Pursue Progress. Discover Extraordinary.

Join Sanofi and step into a new era of science - where your growth can be just as transformative as the work we do. We invest in you to reach further, think faster, and do what’s never-been-done-before. You’ll help push boundaries, challenge convention, and build smarter solutions that reach the communities we serve. Ready to chase the miracles of science and improve people’s lives? Let’s Pursue Progress and Discover Extraordinary – together.

At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, protected veteran status or other characteristics protected by law.

Watch 'One day at Sanofi' and check out our Diversity Equity and Inclusion initiatives at sanofi.com