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Research and Development

R&D
Where your curiosity drives the
miracles of
science

Senior Principal Scientist - Therapeutic Discovery

Cambridge, Massachusetts Salary Range   USD 147,000.00 - 212,333.33
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At a glance

Bring your curiosity to a team where deep immunoscience meets cutting-edge innovation. Across oncology, rare diseases, neurology, and vaccines, you’ll work at the intersection of lab science and AI-powered discovery — all while collaborating across boundaries to turn breakthrough ideas into real-world impact. Whether you want to deepen your scientific expertise or grow as a leader, you’ll find the opportunity here.

Job Title: Senior Principal Scientist - Therapeutic Discovery

Location: Cambridge, MA

About You

Required Qualifications

  • Bachelor's + 12 years of relevant experience OR

  • Master's + 9 years of relevant experience OR

  • Ph.D. + 7 years of relevant experience

  • Relevant experience in biopharma is preferred

  • Proven track record of leading successful protein-based and/or small molecule discovery projects

  • Deep expertise in immune-related disease biology, models, and therapeutics

  • Extensive experience managing external research collaborations

  • Strong record of building and leading research teams

Core Competencies

  • Strategic thinking and decision-making capability

  • Excellence in scientific leadership and team development

  • Outstanding project and resource management skills

  • Strong business acumen and stakeholder management ability

  • Proven ability to drive innovation in a fast-paced environment

Impact

  • Shape and implement research strategy for novel therapeutic modalities

  • Build foundational capabilities for Intrépide's US operations

  • Drive critical decision-making for pipeline advancement

  • Develop and mentor next generation of scientific leaders

Why Choose Us?

  • Bring the miracles of science to life alongside a supportive, future-focused team.

  • Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

  • Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

  • Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

  • Opportunity to shape the future of therapeutic discovery

  • Highly collaborative, science-driven culture

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.

Pursue Progress. Discover Extraordinary.

Join Sanofi and step into a new era of science - where your growth can be just as transformative as the work we do. We invest in you to reach further, think faster, and do what’s never-been-done-before. You’ll help push boundaries, challenge convention, and build smarter solutions that reach the communities we serve. Ready to chase the miracles of science and improve people’s lives? Let’s Pursue Progress and Discover Extraordinary – together.

At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, protected veteran status or other characteristics protected by law.

Watch 'One day at Sanofi' and check out our Diversity Equity and Inclusion initiatives at sanofi.com

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Why work with us

  • Expand your horizons. Grow through curiosity, with support to move, learn, and lead in a culture that champions mentorship, mobility, and bold development.

  • Accelerate results with technology. Harness the power of AI and automation to push scientific boundaries and reimagine what's possible in drug discovery.

  • Impact through inclusive innovation. Help deliver better science and fairer outcomes by driving inclusive research that reaches more people, in more meaningful ways.

  • Turn patient needs into breakthrough science. Drive scientific breakthroughs that start with patient needs – and end in treatments that change lives.

Meet Nils Libert, Associate Scientist

Meet Nils Libert, an Associate Scientist in Belgium, where he plays a key role in advancing groundbreaking research. Learn how his work helps drive innovation, uncover new scientific possibilities, and contribute to life-changing treatments that impact patients around the world.

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"At Sanofi, we are building an R&D engine powered by the best science, digital innovation, and a commitment to transforming the lives of patients around the world."

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EVP & Head of R&D

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Discover how we're reshaping the future of medicine through immunoscience – unlocking bold, cross-disease breakthroughs that were unimaginable just a decade ago.

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