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Job Title: Senior Scientist - RNA-Molecular Biology and Rare Neurological Diseases

About the Job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress. 

We are seeking a highly motivated and skilled Senior Scientist with deep expertise in RNA biology and  and rare diseases—particularly affecting the central nervous system, including rare neurodegenerative conditions such as Huntington’s disease, and leukodystrophies. The ideal candidate will bring robust hands-on experience in RNA regulation, RNA-binding proteins, and computational biology, combined with a strong foundation in disease biology.

In this role, you will lead efforts to discover and validate novel RNA-based therapeutic targets and strategies, leveraging both wet-lab and computational approaches. Your work will play a critical role in advancing our rare disease pipeline, particularly in rare CNS-related indications. You will collaborate closely with cross-functional teams to translate scientific insights into new programs, contributing to the strategic expansion of our therapeutic portfolio.

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?

Main Responsibilities:

• Drive new program initiation by applying expertise in disease mechanisms and RNA biology

• Design, develop, and implement computational tools for the analysis of high-throughput sequencing datasets, with a focus on RNA-level insights

• Leverage molecular biology skills in combination with disease area expertise to translate computational findings into actionable biological hypotheses and experimental designs in the context of rare neurological/neurodevelopmental disorders

• Design and conduct in vitro and in vivo mechanism-of-action, and proof-of-concept studies to validate targets and evaluate therapeutic strategies

• Contribute to interdisciplinary research programs in a highly collaborative manner across internal groups and with external partners, with opportunity to grow into a project leadership role

• Prepare high-quality analyses, interpretation, documentation, and presentations to support project milestones, publications, patent filings, and potentially regulatory (IND/CTA) filings

• Present findings and progress in internal meetings and external venues as appropriate (e.g., publications, conferences, collaboration and governance meetings)

About You

Basic Qualifications:

• Ph.D. in a scientific field with relevant experience in industry or academia; or a master’s degree with 4+ years of relevant experience; or bachelor’s degree with 6+ years relevant experience.

• Degrees in Molecular Biology, Cellular Biology, or a related discipline is preferred

• Deep expertise in RNA and molecular biology, including RNA regulation and processing (e.g., splicing, stability, transport), and the roles of regulatory RNAs and RNA-binding proteins

• Proficiency in computational and bioinformatics techniques, including RNA-seq analysis, isoform and splice-site mapping, and off-target prediction

• Demonstrated ability to produce high-quality scientific documentation, including experimental protocols, standard operating procedures (SOPs), technical reports, and presentations

• Proven track record of meaningful contributions to research programs, evidenced by scientific publications and/or presentations

Preferred Qualifications:

• Hands-on experience with disease-relevant in vitro and/or in vivo models, including functional and phenotypic assays

• Technical proficiency in iPSC culture, gene expression analysis, molecular cloning, vector design, gene editing (e.g., CRISPR), and RNA sequencing (bulk and single-cell)

• Experience with discovery, optimization, and development of siRNAs and/or ASOs (degrading and skipping) is a plus

• Experience performing in vivo studies in rodent models

• Familiarity with drug discovery and development processes

Skills and competencies:

• Ability to work independently and collaboratively within cross-functional, matrixed teams

• Highly adaptable, with strong multitasking skills and the ability to manage shifting priorities and timelines

• Strong analytical and problem-solving skills with sound scientific judgment

• Clear written and verbal communication skills, with the ability to convey complex concepts clearly

• Interpersonal strengths that foster effective collaboration and the ability to build productive working relationships

• Outstanding organizational skills, attention to detail, and commitment to maintaining rigorous documentation

Why Choose Us?

• Bring the miracles of science to life alongside a supportive, future-focused team.

• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.

Pursue Progress. Discover Extraordinary.

Join Sanofi and step into a new era of science - where your growth can be just as transformative as the work we do. We invest in you to reach further, think faster, and do what’s never-been-done-before. You’ll help push boundaries, challenge convention, and build smarter solutions that reach the communities we serve. Ready to chase the miracles of science and improve people’s lives? Let’s Pursue Progress and Discover Extraordinary – together.

At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, protected veteran status or other characteristics protected by law.

Watch 'One day at Sanofi' and check out our Diversity Equity and Inclusion initiatives at sanofi.com