Principal Scientist 1, Metabolism - all genders (limited for 2 years)

About the job

Join the Metabolism Research Group at Sanofi Frankfurt

The Metabolism Research group at Sanofi's BioCampus Frankfurt is a vital component of our global Lab Science/TMU organization. We are at the forefront of biotransformation research, specializing in the elucidation of metabolite for both new chemical and biological entities.

Our team's core objectives span all global Sanofi programs and include:

• Identifying metabolic liabilities: We pinpoint potential issues early in research up to the drug development process.
• Optimizing drug candidates: Our work directly contributes to enhancing the efficacy and safety of potential treatments.
• Detecting reactive metabolites: We strive to mitigate risks of adverse effects, ensuring safer drug development.
• Discovering pharmacologically active metabolites: Our investigations may uncover new therapeutic candidates.

As part of Sanofi's innovative Immunoscience approach, we collaborate closely with multidisciplinary teams, including experts in research, development, pharmacology, and toxicology.

Your Main Responsibilities:

• Conduct independently biotransformation studies of novel biotherapeutics (nanobodies, antibodies) within our metabolism laboratory team.
• Develop and implement tailored LC-MS strategies and workflows to each project/construct to analyze in vitro and in vivo studies and to identify biotherapeutic degradation products
• Drive innovation by implementing cutting-edge analytical technologies and proteomic/metabolite identification software
• Develop automated workflows to enhance efficiency in data evaluation and establish models predicting biotherapeutics instabilities
• Present and discuss your results to global metabolism experts, to the project teams, and Lab Sciences colleagues

About you

Required Qualifications:

• Extensive hands-on experience with:
  • Ultra-high resolution MS instrumentation
  • Multiple fragmentation techniques (CID/ETD)
  • Manual MS spectra interpretation

• Proven expertise in protein characterization methodologies (Top-Down, Middle-Down, Bottom-up approaches) and extraction technologies (immunocapture approach)
• Advanced MS data processing and analysis capabilities, preferably for proteomics analyses
• Experiences in protein chromatography (µPLC/micro-LC/nano-LC)

Professional Skills:

• Excellent communication and presentation skills
• Track record of contributing to scientific publications
• Strong collaborative mindset for cross-functional team environments
• Experience in biotransformation of biotherapeutics (preferred)

Education:
PhD degree in biochemistry, analytical chemistry, food chemistry, or pharmacy

LanguageRequirements: German/English: fluent in speaking, reading, writing

Why choose us?

• Bring the miracles of science to life alongside a supportive, future-focused team.
• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
• Benefit from a well-thought-out benefits package that rewards your contribution and commitment.
• Start your career at an attractive location in the center / in the capital of Germany and experience our modern working environment and benefit from hybrid, flexible working time models.

Pursue Progress. Discover Extraordinary.

Progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. You can be one of those people. Chasing change, embracing new ideas and exploring all the opportunities we have to offer. Let’s pursue progress. And let’s discover extraordinary together.

At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, or gender identity.

Watch our ALL IN video and check out our Diversity Equity and Inclusion actions at sanofi.com!

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