R&D - Intrepide China - Sr. Scientist I - Suzhou

Sanofi is an innovative global healthcare company, driven by one purpose: we chase the miracles of science to improve people’s lives. Our teams across the world strive to transform the practice of medicine, turning the impossible into the possible for patients. SIBR is an integral part of Sanofi Global R&D and spearheading the organization's drive towards innovation through strategic partnerships with various external entities in China. We aspire to identify and leverage innovation opportunities to enrich the Global Research portfolio and ensure a sustainable growth of our R&D pipeline.

About the position

We are seeking an exceptional, energetic, and self-motivated protein scientist who will be deeply involved in the scientific and experimental assessment of novel preclinical protein therapeutics and protein-based technology opportunities. The scope of our research focuses on developing innovative protein-based therapeutics in Immunology & Inflammation (I&I), Neuroinflammation, and Oncology. This role will be instrumental in advancing our large molecule drug discovery efforts, leveraging state-of-the-art protein science techniques to develop next-generation therapeutics. The successful candidate will work collaboratively within cross-functional teams to drive protein-based drug discovery from concept to preclinical development. The ideal candidate will have expertise in cutting-edge protein technologies, including but not limited to engineered antibodies and antibody-drug conjugates, bispecific and multi-specific protein scaffolds, protein degraders, novel protein modalities and targeted protein delivery systems, AI-assisted protein design and optimization.

Key responsibilities

• Lead studies on protein structure, biochemistry, characterization, and developability for large molecule drug discovery

• Design and execute protein expression, purification, and analytical characterization workflows

• Perform protein engineering and optimization to enhance stability, solubility, and functionality

• Conduct biophysical analyses including thermal stability, aggregation propensity, and binding kinetics

• Employ techniques such as ELISA, SPR, DSC, SEC, and mass spectrometry for protein characterization

• Lead the validation of external protein assets and support evaluation of emerging protein technologies

• Contribute to research projects focused on therapeutic protein development for immune-mediated and neurodegenerative diseases

• Engage in communications within cross-functional and global project teams

Qualifications

• PhD in biological, biomedical, and pharmaceutical sciences, candidate with demonstrated expertise in Protein Science is highly desirable

• At least 3 years of post-degree research experience

• More than 5 years of hands-on experience in protein science, including the purification of a variety of recombinant proteins/antibodies, and in process analyses (SE-UPLC/RP-UPLC, LC-MS)

• Extensive knowledge and research experience in therapy areas such as I&I, CNS, and oncology, as demonstrated by publications, patents, and/or licensing agreements

• Proven track-record of effective project management and problem-solving ability

• Experience in monitoring and tracking CRO conducted studies and other research activities

• Be able to effectively communicate in English and Mandarin in a highly multi-disciplinary and culturally diverse environment

• Skills for accurately reporting and interpreting experimental results, including proper documentation, report writing, and data analysis