Senior Principal Scientist I

Job title: Senior Principal Scientist I

Location: Waltham, MA

About the job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress.

Position Overview:

The Genomic Medicine Unit at Sanofi is seeking a dynamic and visionary Scientist to join our team focused on Ocular Genomic Medicines. This is a rare opportunity to shape the future of ophthalmic therapeutics by pioneering advancements in gene therapy, gene editing, and RNA-based technologies. In this role, you will provide scientific leadership and strategic direction to drive the development of Sanofi’s Ophthalmology pipeline. You will work collaboratively across cross-functional teams to design and implement innovative therapeutic strategies, translating cutting-edge genomic medicine platforms into clinical solutions.

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?

Main Responsibilities:

• Lead programs evaluating novel AAV capsids for targeted ocular delivery and disease applications.

• Drive the implementation of gene editing platforms for ocular indications.

• Oversee research on the delivery of therapeutic microRNAs, siRNAs, and ASOs for ocular diseases.

• Develop and refine gene regulation strategies tailored to ocular applications.

• Assess the therapeutic potential of genomic medicines in relevant ocular disease models.

• Enable translation from in vitro/in vivo POC studies to therapeutic disease programs for preclinical & clinical development.

• Contribute to interdisciplinary genomic medicine programs in a highly collaborative and matrixed manner across internal groups and with external partners.

• Manage highly functional teams

• Represent Sanofi at external scientific meetings

• Lead the writing of patents and publications

• Participate actively in external collaborations

About You

Qualifications:

• Ph.D. in Molecular Biology, Genetics, Biomedical Sciences, or a related field with at least 8 years’ relevant experience.

• Proven track record in ocular and/or genomic medicine translational sciences.

• Comprehensive experience with biochemistry, cellular biology, and molecular biology.

• Experience in translating programs through development to IND filing a plus.

• Experience leading scientific teams and managing complex translational programs.

• Deep understanding of AAV gene therapy, gene editing, and RNA-based therapeutics.

• Strong publication record and ability to communicate scientific vision effectively.

• Demonstrated excellent analytical, interpersonal, written, and oral communication skills; ability to communicate effectively with scientists and with non-scientists

Why Choose Us?

• Bring the miracles of science to life alongside a supportive, future-focused team.​​

• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.​​

• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.​​

• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.​

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants
will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic
partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability
for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or
any other characteristic protected by law.

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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.