Job title: Senior Associate Scientist, Bioimaging, Immunohistology and Immunology

• Location: Marcy L' Etoile

About the job

As an experienced Bioimaging Associate Scientist, you will oversee designing, performing and optimizing in vivo imaging studies to characterize mRNA-LNP formulations and to decipher mode of actions.

Main responsibilities:

• Design, perform and optimize in vivo imaging studies to characterize new vaccine candidates in adequate preclinical models. Creating and developing advanced in vitro, in vivo and ex vivo studies utilizing nucleic acid bio-analytics, and wide range of preclinical, cell biology and optical microscopy analysis

• Especially use bioimaging tools to support mRNA and Lipid Nanoparticles process Development and Optimization. Coordinate the bioimaging activities, compile the analytical data package to support advancement of mRNA and other development candidates

• Design and troubleshoot protein and molecular assays for use on in vitro and in vivo samples including: mammalian cell transfections, ELISA, functional antibody assays, flow cytometry, reporter assays, activity assays

• Design and troubleshoot cell-based methods and immunoassay methods

• Critically analyze, interpret, and report experimental results; draw appropriate conclusions and design next steps. Contribute to the protocol, report writing when appropriate including reports to include in Health Authorities dossiers

• Work in highly collaborative cross functional teams. Make scientific presentation and report project Progress in mRNA center of excellence team meetings in both languages, English and French

• Ensure timely completion of assignments and deliverables

About you

Experience:

• High experience in bioimaging and animal sciences

• At least 3+ years in mRNA field and 10+ years of pharma/biotech

• Skilled in bioimaging and ability to perform complex method, in vivo model development and propose appropriate method improvement

• Experience in computerized tomography, bioluminescence and fluorescence imaging

• Experience in optical imaging with IVIS Spectrum-CT, Cellvizio fibered Laser Endomicroscope and Kaer Imaging System. Able to use M3 Vision, Living Image, ICViewer, ImageJ/Fiji and KIScontrol softwares

• Experience in pharmacology in vivo, Surgery models, Pathophysiology, Histology and Immunohistochemistry

• Management of preclinical sample and collection (blood, serum, organs, etc.)

• French License on animal experimentation in biology is mandatory: FELASA category B or C

• Experience in working with biosafety level 2 and 3 constraints and Specific Pathogen Free animal facilities

• Experience in mammalian cell culture and transfection, ELISA, functional antibody assays and flow cytometry would be really appreciated

• Proven capability of evaluating/developing new technologies

• Experienced working with highly technical projects with reactivity

• Able to work independently and collaborate in team, enthusiastic and self-motivated

Languages:

• Excellent verbal and written communication skills in English and French

Education:

• Bachelor’s degree or MSc/Engineer

As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. This position will require individuals to be fully vaccinated against Flu as part of your job responsibilities.

Pursue Progress. Discover Extraordinary.

Progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. You can be one of those people. Chasing change, embracing new ideas and exploring all the opportunities we have to offer. Let’s pursue progress. And let’s discover extraordinary together.

At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, or gender identity.

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