Manufacturing and Supply
Where the
miracles of
science are made
a reality for patients
Site Head Operations - Pearl River, NY
At a glance
Our teams produce and deliver over 4 billion units of medicines and vaccines every year, ensuring every breakthrough gets to the people who need it most.
Our state-of-the-art facilities, AI-powered smart factories, and cutting-edge automation are redefining what’s possible: ensuring treatments reach patients faster, safer, and more sustainably than ever before. This is where your skills, ambition, and passion can shape the future of healthcare.
Job title: Site Head Operations - Pearl River, NY
Location: Pearl River, NY
About Sanofi
We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.
About the job
Join a global network that powers how Sanofi delivers — seamlessly, purposefully, and at scale. In Manufacturing & Supply, you’ll help reimagine how life-changing treatments reach people everywhere, faster.
The Site Head of Operations at Pearl River is responsible for driving strategic development, innovation, and continuous quality improvement to manufacture vaccines that meet the highest safety, quality, regulatory, and cost standards while delivering on schedule. This leader collaborates with M&S Vaccines US leadership to develop and execute medium- and long-term strategic plans, anticipating evolving customer needs and ensuring sustainable peak performance in a dynamic environment. The role encompasses leading government agency and community stakeholder engagement, overseeing site support services, and fostering strong employee relations and communications across all organizational levels.
Dimensions/Scope:
Responsible for timely supply of Flublok and Flublok Trivalent products to global market delivering about 14M million doses in 2026, and the Pearl River budgeted portion up to 2026 representing >US$300 million in sale value.
Manage manufacturing annual site spending levels ensure to meet budget commitments. Support overall site spending aligning with other functions (~US$45 million).
Ensure manufacturing count targets are maintained (~105 RHC) and work cross functionally to support overall headcount (~105 RHC).
Support site strategic projects to ensure 100% milestones are achieved on time and budget.
Main Responsibilities:
Leads the Site Strategy, Planning and Development: Align Site Master Plan with M&S Vaccines US strategy; oversee budget, CAPEX, and headcount projections; ensure cGMP compliance and emergency preparedness.
Manufacturing and Supply: Drive product supply to meet global demand at optimal cost; manage inventory strategy, CMO partnerships, and optimized resource utilization.
Quality & Compliance: Ensure highest regulated standards; maintain Quality Objectives; serve as primary contact for governmental audits and compliance reviews.
Health, Safety, Environment & Security: Ensure highest regulated standards; maintain Quality Objectives; serve as primary contact for governmental audits and compliance reviews.
Government & Community Relations: Manage relationships with regulators and stakeholders; build networks to anticipate industry developments and protect company performance.
Innovation and Continuous Improvement: Champion new technologies and process improvements to reduce costs and enhance quality; foster a culture of excellence and transparency.
About You
Minimum Requirements
Bachelor’s degree in Engineering or Biological Sciences required
Masters or MBA preferred
15-+ years direct operating experience in Pharma/Biotech, Industrialization, Project Management, and Quality in a global, matrix environment
Demonstrated leadership and behavior competencies
Demonstrated large scale complex Supply Chain Manufacturing Management experience and expertise
Strong people management skills
Demonstrated experience with complex budget, financial controls, capital project leadership and development
Demonstrated experience interfacing with Governmental agencies and regulatory boards.
Certifications:
Lean Six Sigma certification – green or black belt or other certifications (preferred)
Why Choose Us?
Bring the miracles of science to life alongside a supportive, future-focused team.
Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
Why Choose Us?
Bring the miracles of science to life alongside a supportive, future-focused team.
Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.
Pursue Progress. Discover Extraordinary.
Join Sanofi and step into a new era of science - where your growth can be just as transformative as the work we do. We invest in you to reach further, think faster, and do what’s never-been-done-before. You’ll help push boundaries, challenge convention, and build smarter solutions that reach the communities we serve. Ready to chase the miracles of science and improve people’s lives? Let’s Pursue Progress and Discover Extraordinary – together.
At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, protected veteran status or other characteristics protected by law.
Watch 'One day at Sanofi' and check out our Diversity Equity and Inclusion initiatives at sanofi.com
Final compensation will be determined based on demonstrated experience, skills, location, and other relevant factors. Employees may be eligible to participate in Company employee benefit programs.
Find out more about this location
Why work with us
- We’re problem-solvers and pioneers. United by the belief that everyone deserves a healthier future. We create best-in-class vaccines that prevent disease and protect lives.
- Innovation drives us. From AI and mRNA to next-gen science, we push the boundaries to deliver first- and best-in-class vaccines for infectious diseases worldwide.
- Growth happens here. With bold investments in R&D and world-class facilities, Sanofians across the entire vaccine lifecycle are shaping the future of global health.
- We do what’s right. Sustainability and DE&I drive our positive global impact—because the diverse communities Sanofians represent are the patients we serve.
All-in on diversity
At Sanofi, diverse perspectives fuel the best solutions for patients. Hear from Monique Vessey, our Supply Chain Transformation Leader, on how her background shapes her approach to delivering life-changing medicines.
"Manufacturing and Supply is the bridge between the science that happens in research laboratories and the people and communities we serve."
Brendan O’Callaghan
Executive Vice President of Manufacturing and Supply
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