Manufacturing and Supply
Where the
miracles of
science are made
a reality for patients
Head of Site OPEX and Smart Factory
At a glance
Our teams produce and deliver over 4 billion units of medicines and vaccines every year, ensuring every breakthrough gets to the people who need it most.
Our state-of-the-art facilities, AI-powered smart factories, and cutting-edge automation are redefining what’s possible: ensuring treatments reach patients faster, safer, and more sustainably than ever before. This is where your skills, ambition, and passion can shape the future of healthcare.
About the Job
Sanofi Manufacturing and Supply organization is preparing its future through an ambitious program named Modulus. The Modulus Project is at the cornerstone of Sanofi strategy as it aims at creating a new manufacturing concept consisting of a new generation of evolutive multi-product facilities, modular, adaptable and agile, leveraging new disruptive technologies, to better address vaccine business challenges as well as Specialty Care Biologics products.
As a Head of Site OPEX and Smart Factory, you will be:
Developing, owning, and maintaining the Site Performance Roadmap by:
Leading the Strategy Cascading process by working closely with internal (i.e., SLT) and external (i.e., Global Functions) stakeholders, defining site CBN’s
Drive internal/external benchmarking & analyses to identify performance gaps/opportunities vs. best in class, socializing it internally and externally with key stakeholders
Leading the performance & digital piece during Strat Plan and Budget, defining performance ambition (aligned with CBN’s and GBU objectives), cascaded into financial/operational targets across all performance dimension (e.g., +QDCI, scorecard)
Developing a prioritized portfolio of initiatives (i.e., performance + modernization) to deliver site ambition, and related: impact, resourcing, and timelines
Delivering performance ambition by leading the execution of the Site Performance Roadmap through:
Focused transformation initiatives (e.g., performance boosters), when fast-paced performance breakthroughs are required
Standardization through SMS 2.0 ecosystem deployments enabling continuous improvement (incl. execution support, CI standard deployment, problem solving, OpEx method, etc.)
Deployment of Smart Factory solutions (incl. AI) and associated change management to ensure value realization and expected transformation (e.g., Modernization Index)
Supplier Excellence: Own the Material & Supplier improvement initiatives (i.e., Supplier Excellence) & business interface of the procurement on site
Leading site performance governance by:
Manage operational KPI management (i.e., +QDCI) including cascaded review from shopfloor to SLT to track performance evolution vs. ambition
Drive financial impact of performance actions (e.g., 3P, Sievo) ensuring value is maximized and captured in alignment with Finance, Procurement, Operations
Monitor overall performance trajectory vs. ambition, spot early on (risk of) deviations and decide appropriate corrective actions
Represent the site in above site performance reviews and forums
Leading Site SMS team and developing OpEx & Digital capabilities & performance culture
Implement Site OpEx & Smart Factory team in alignment with standard organization
Modernize OpEx capabilities by developing strong digital (e.g., Data Analytics, AI, Connectivity) profiles
Drive OpEx and Digital training in alignment with the learning administrator
Develop strong relationships with the global OpEx community and the Global
About You
Knowledge of main Operational Excellence techniques (e.g., Lean, Six Sigma, Agile, CI, etc.)
Experience in transformation and change management
Understanding of data analytics / visualization
Project Management
Basics of finance and strategy
Knowledge of main IT/Digital solutions (e.g., ERP)
Knowledge of Manufacturing 4.0 (Paperless manufacturing operation with integrated information flow across different platform across SAP, MES, Delta V, Historian, LIMS etc)
Knowledge and proven application of AI/Gen AI tools
Knowledge of key business & pharma processes
Pursue Progress. Discover Extraordinary.
Join Sanofi and step into a new era of science - where your growth can be just as transformative as the work we do. We invest in you to reach further, think faster, and do what’s never-been-done-before. You’ll help push boundaries, challenge convention, and build smarter solutions that reach the communities we serve. Ready to chase the miracles of science and improve people’s lives? Let’s Pursue Progress and Discover Extraordinary – together.
At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, protected veteran status or other characteristics protected by law.
Watch 'One day at Sanofi' and check out our Diversity Equity and Inclusion initiatives at sanofi.com
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Why work with us
- We’re problem-solvers and pioneers. United by the belief that everyone deserves a healthier future. We create best-in-class vaccines that prevent disease and protect lives.
- Innovation drives us. From AI and mRNA to next-gen science, we push the boundaries to deliver first- and best-in-class vaccines for infectious diseases worldwide.
- Growth happens here. With bold investments in R&D and world-class facilities, Sanofians across the entire vaccine lifecycle are shaping the future of global health.
- We do what’s right. Sustainability and DE&I drive our positive global impact—because the diverse communities Sanofians represent are the patients we serve.
All-in on diversity
At Sanofi, diverse perspectives fuel the best solutions for patients. Hear from Monique Vessey, our Supply Chain Transformation Leader, on how her background shapes her approach to delivering life-changing medicines.
"Manufacturing and Supply is the bridge between the science that happens in research laboratories and the people and communities we serve."
Brendan O’Callaghan
Executive Vice President of Manufacturing and Supply
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