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mRNA - Computational Biology - Principal Data Scientist- Vaccines

Waltham, Massachusetts
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Every day, 2.5 million Sanofi vaccine doses reach patients worldwide - powered by bold ideas, cutting-edge science, and passionate people like you. Across every stage — from discovery to delivery — Sanofians are shaping the future of vaccines. In global R&D hubs, exceptional offices, and state-of-the-art manufacturing sites, we’re reimagining what’s possible. But science alone isn’t enough — it’s the extraordinary minds behind it that truly make the difference.

Job title: mRNA - Computational Biology - Principal Data Scientist- Vaccines

Location: Waltham, MA

About the Job

At Sanofi, we believe in a world in which no one suffers or dies from vaccine-preventable diseases. The pandemic has sustainably transformed our industry, creating new opportunities and challenges. At Sanofi, we are convinced that accelerating the innovation of mRNA technology means better vaccine accessibility for all populations, faster than before.

For this reason, we are looking for bold, optimistic collaborators for our new team at the mRNA Center of Excellence. We are investing €400 million in this brand-new center, where 400 employees are dedicated to this technology work.

Sanofi's mRNA Center of Excellence seeks an outstanding Computational Biologist, Principal Scientist to join the Data and Computational Science team. This pivotal role will drive the development of next-generation mRNA vaccines and therapeutics using cutting-edge data science and machine learning approaches. By leveraging state-of-the-art AI and analytics, the candidate will orchestrate the creation of advanced predictive models for clinical outcomes and extract critical insights to accelerate the development of innovative mRNA products. We seek a visionary data scientist with comprehensive knowledge and proven experience in delivering transformative solutions through various analytical techniques, playing a crucial role in advancing Sanofi's position as a global leader in this revolutionary field.

We are an innovative global healthcare company that helps the world stay ahead of infectious diseases by delivering more than 500 million vaccine doses a year. Across different countries, our talented teams are exploring new technologies to protect people and promote healthy communities. We chase the miracles of science every single day, pursuing progress to make a real impact on millions of patients around the world. The future of Sanofi depends on your ambition, your commitment. Join.

Main Responsibilities:

  • Pioneer Predictive Models: Lead the development of groundbreaking computational models to predict clinical immunogenicity and reactogenicity of mRNA vaccines and therapeutics.

  • Unravel Complex Data: Oversee the analysis and integration of diverse, multi-modal datasets to gain unprecedented insights into mRNA vaccine and therapeutic efficacy and safety.

  • Strategic Leadership: Contribute to the development & prosecution of an overall computational biology strategy for mRNA Translational Research, aligning with Sanofi's long-term goals and industry trends.

  • Drive Data-Informed Decisions: Lead cross-functional collaborations to accelerate mRNA product development through data-driven strategies and influence key stakeholders.

  • Shape the Future of mRNA: Direct the development of foundational models to enhance our understanding of mRNA biology and its applications in vaccine and therapeutic development.

  • Project/Program Leadership & Management: Lead and manage complex research and technical projects or programs to deliver on Translational Strategy.

  • Innovate and Protect: Generate intellectual property and contribute to patent filings and scientific publications, securing Sanofi's position at the forefront of mRNA technology.

About You

  • Earned Ph.D. in Computational Biology, Bioinformatics, or related field with a strong focus on data science and machine learning.

  • 5+ years of experience applying advanced computational approaches to biological problems, preferably with significant experience in vaccines or immunology.

  • Demonstrated expertise in developing and implementing novel statistical & machine learning techniques for biological data analysis within the pharmaceutical/biotech industry is highly preferred.

  • Advanced proficiency in Python, R, and extensive experience with cloud computing platforms and big data technologies.

  • Solid understanding of immunology and vaccine development processes, with the ability to translate complex biological concepts into computational strategies is extremely helpful.

  • Proven track record of leading projects involving diverse, multi-modal datasets, including genomics, proteomics, flow cytometry, and clinical data.

  • Excellent communication skills, ability to present complex findings to both technical and non-technical audiences.

  • Publication record in high-impact journals and presentations at international conferences is highly preferred.

About your development opportunities

In this role, you will be part of a unique team bridging the gap between preclinical research and clinical outcomes and directly contribute to the understanding and advancement of Sanofi’s mRNA platform for the treatment and prevention of disease.  You’ll be faced with interesting challenges in a supportive atmosphere, and you’ll have the opportunity to hone your skills and expertise as a computational biologist delivering impactful and actionable solutions to the organization.

Why Choose Us?

  • Bring the miracles of science to life alongside a supportive, future-focused team.

  • Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

  • Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

  • Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law

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Why work with us

  • We’re problem-solvers and pioneers - united by the belief that everyone deserves a healthier future. We create best-in-class vaccines that prevent disease and protect lives.

  • Innovation drives us. From AI and mRNA to next-gen science, we push the boundaries to deliver first- and best-in-class vaccines for infectious diseases worldwide.

  • Growth happens here. With bold investments in R&D and world-class facilities, Sanofians across the entire vaccine lifecycle are shaping the future of global health.

  • We do what’s right. Sustainability and DE&I drive our positive global impact—because the diverse communities Sanofians represent are the patients we serve.

What does it take to protect the world from disease?

For over a century, we’ve been pioneering breakthroughs that help protect millions from diseases like polio, influenza, RSV, and more. And we’re not stopping there.

Powered by groundbreaking technologies - mRNA platforms, recombinant proteins, and AI-driven insights - we’re pushing the boundaries of science.

"I’m immensely proud of the pace of our innovation – the urgency by which our teams are working to transform the practice of medicine."
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Thomas Triomphe

Executive Vice President, Vaccines

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Sanofi’s mRNA Center of Excellence

Step into the future of healthcare with Sanofi’s mRNA Center of Excellence. Discover how a global team is transforming medicine with cutting-edge mRNA technology – and explore the skills, inspirations, and breakthroughs driving this revolution. Ready to shape the future?

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About Sanofi Vaccines

Explore our commitment to protecting global health through the power of vaccines. We’re building healthier communities with innovative solutions that save millions of lives each year. Dive into the future of vaccines, discover the diseases we’re tackling, and learn why vaccination is critical at every stage of life.

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