R&D
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Senior Associate Scientist - Neurodegenerative Disease Research

Location: Cambridge, MA

About the job

Join our dynamic Neurology Research Therapeutic Area team in Cambridge, MA, where we're dedicated to discovering and developing innovative therapies for patients suffering from neurodegenerative diseases. Our multidisciplinary team combines cutting-edge science with a collaborative approach to tackle some of the most challenging diseases affecting the central nervous system, including Alzheimer's, Parkinson's, and ALS. We are committed to advancing the understanding of disease mechanisms and translating these insights into meaningful therapeutic solutions for patients.

Main Responsibilities

• Perform experiments and studies in support of neurodegenerative disease research projects and company drug discovery goals
• Design, execute, and troubleshoot experiments in both in vivo and in vitro settings
• Establish and optimize iPSC-derived neuronal and glial cell culture models for disease modeling and drug screening
• Analyze, interpret, and present experimental results to team members and project stakeholders
• Develop and maintain neurodegenerative disease models, including handling laboratory animals
• Conduct animal procedures including necropsy, various injection routes (IV, IP, SC), and assist with intracranial stereotaxic surgeries
• Perform cell culture techniques, qPCR, ELISA, and plate-based assays (MSD/SIMOA)
• Execute microscopy and cell-based imaging techniques to evaluate cellular phenotypes
• Integrate multi-omics and human biology data to guide target validation and model development
• Maintain detailed and accurate laboratory records following scientific rigor standards
• Collaborate effectively with team members and contribute to a positive team environment
• Support the development of new methodologies and approaches as needed
  

Qualifications & Experience

• Bachelor's Degree plus minimum 4 years of relevant research experience in an academic or biopharmaceutical setting OR Master's Degree plus minimum 1 year of relevant research experience
• Strong technical expertise in neuroscience research techniques
• Experience with in vivo models of neurodegenerative diseases, including animal handling, necropsy, and various injection routes (IV, IP, SC)
• Proficiency in cell culture techniques, including 2D and 3D culture systems
• Experience integrating human biology datasets (e.g., genomics, transcriptomics) into experimental workflows
• Proficiency in qPCR, ELISA, and plate-based assays (MSD/SIMOA)
• Experience with microscopy and cell-based imaging techniques
• Demonstrated ability to work in a team environment and collaborate effectively
• Excellent documentation and record-keeping skills
• Strong analytical and problem-solving abilities
• Ability to prioritize and organize work to meet project deadlines
• Knowledge of laboratory safety procedures and good laboratory practices

Preferred Qualifications

• Experience with iPSC-derived cultures, including neuronal monocultures and co-cultures with glial cells in both 2D and 3D formats
• Cell culture electrophysiology experience (MEA, calcium imaging)
• Experience with binding assays for complex biologics (SPR, BLI/Octet)
• Experience with high-throughput screening and assay development
• Experience with intracranial stereotaxic surgeries
• Background in neurodegenerative disease research
• Familiarity with bioinformatics tools and data analysis software
• Previous experience in pharmaceutical or biotechnology research settings
  

What We Offer

• Opportunity to contribute to groundbreaking research in neurodegenerative diseases
• Collaborative and innovative work environment
• Professional development and growth opportunities
• Competitive compensation and benefits package
• State-of-the-art research facilities

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.

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Rejoignez Sanofi et entrez dans une nouvelle ère de la science – où votre parcours peut être aussi transformateur que le travail que nous accomplissons. Nous investissons en vous pour que vous alliez plus loin, accélériez votre réflexion et accomplissiez ce qui n’a jamais été fait auparavant. Vous contribuerez à repousser les limites, à bousculer les conventions et à concevoir des solutions plus intelligentes pour les communautés que nous servons. Prêt·e à poursuivre les miracles de la science et à améliorer la vie des gens ? Poursuivons le progrès et découvrons l’extraordinaire – ensemble.

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