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Job Title: Senior scientist, Spectral Flow Cytometry, Cell Mediated Immunity

Location: Swiftwater, PA

About the Job

The Senior Scientist for CMI &Automation team will design, develop, qualify, validate, and interpretate cellular immunology methodologies to characterize functional T-cell and B-cell subsets and innate immunity for sample analysis for clinical studies across the Sanofi vaccine portfolio

We are an innovative global healthcare company that helps the world stay ahead of infectious diseases by delivering more than 500 million vaccine doses a year. Across different countries, our talented teams are exploring new technologies to protect people and promote healthy communities. We chase the miracles of science every single day, pursuing progress to make a real impact on millions of patients around the world.

Main Responsibilities:

• In addition to deep immunological expertise, the candidate will be expected to provide mentorship and effectively supervise and train lab personnel to perform assigned tasks while ensuring applicable compliance and regulatory agency standards are met.

• The candidate will serve as key resource as expert technical representation within its organization and on multidisciplinary teams.

• It is expected the candidate remain current on state-of-the art technologies such as high dimensional spectral cytometry and embrace the evaluation of new technologies and automation.

About You

Requirements

Education/experience

• Specialized degree in biological sciences from an accredited University

• B.Sc. + 8 yr experience

• M.Sc. + 5yr experience

• PhD + 1yr experience

• Demonstrated expertise examining antigen-specific immune cell function through in vitro/ex vivo stimulation of human primary PBMCs for intracellular cytokine staining analysis (ICS) as evidenced by scientific publications and presentations at scientific meetings

• In depth knowledge and hands on experience with immunological phenotypic and ICS analysis of multiple cell lineages using multi-parameter flow cytometry and qualification/validation of such assays as well as their downstream analyses and reporting.

• Ability to work with viruses, bacteria and potentially infectious samples from humans (BSL-2 or BSL-2+)

• Lead, mentor and train lab staff

• Strong ability to deliver complex objectives under aggressive timelines in a rapidly changing environment

• Excellent technical, critical thinking and communication (oral and written) skills with ability to manage projects and resolve technical problems independently and also work effectively within cross-functional teams

• Experience working in GXP compliant environment.

Functional/Technical Skills

• Extensive hands-on experience with human PBMC isolation/cryopreservation and culture and treatment of primary cells

• Experience in design, execution and troubleshooting of 22+ colour flow cytometry panels for immunophenotypic and ICS analysis using Cytek Aurora

• In-depth knowledge of various immune subsets

• Considerable experience in the use of flow cytometry analysis software OMIQ

• Strong laboratory experience and understanding of clinical and non-clinical flow cytometry assay development, validation and implementation

• Understanding of GXP practices and procedures required.

Preferred experience and skills:

• Hands-on experience with liquid handlers and end-to-end automation

• Knowledge of bioinformatics and statistical analysis is desirable

• Hands on experience with high-dimensional data analysis (e.g. tSNE, UMAP, CITRUS, FlowSOM)

• Hands on experience with automated data analysis including sample QC during clinical testing

• In-depth understanding of the vaccine development process and comprehensive knowledge of the principles and concepts of immunogenicity assay validation, clinical testing and regulatory submission for regulated vaccine bioanalytical assays and strategies

• Be a highly motivated team player with the ability to interact effectively within a multi-disciplinary team

Why Choose Us?

• Bring the miracles of science to life alongside a supportive, future-focused team.

• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.