Scientist

Job Title: Scientist

Location: Cambridge, MA

About the Job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress. 

We are looking for a highly qualified and motivated scientist to join the precision neurology and neuroinflammation cluster, focused on discovering, validating, and developing therapies for neurodegenerative diseases including Alzheimer’s, Parkinson’s, and ALS. This position is laboratory-based and will involve executing experiments to identify and test new therapeutics in vitro and in vivo. The successful candidate will have experience working in neurodegeneration in an academic or industry setting, with extensive experience running animal studies in models of brain disease and the ability to perform cell culture-based experiments using primary brain cells and/or cell lines. The ideal candidate will also have experience running different bioanalysis assays including ELISA based systems.

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?​

Main Responsibilities:

• Run animal studies to assess compound pharmacokinetics using different administration approaches including subcutaneous, intravenous, and surgical ICV dosing.

• Validate in vivo mouse models of neurodegenerationto measure target engagement and tease apart disease mechanisms.

• Establish new animal protocols, manage AUPs, and coordinate studies in compliance with in vivo best practices.

• Establish primary, immortalized, and/or iPSC-based cell cultures to test compounds or model neuroinflammatory mechanisms.

• Measure compound exposure and changes in neuroinflammatory pathways in the CNS using ELISA or other similar approaches.

• Provide support for externally run studies by communicating with vendors and collaborators.

• Help design and execute experiments, analyze data, and clearly communicate results at internal and external meetings.

• Interact in a matrixed, dynamic and cross-functional manner across the Rare and Neuroscience Therapeutic Area and research platforms.

• Help guide new drug candidates from the early exploratory discovery stage to the clinic.

About You

QUALIFICATIONS, COMPETENCIES & CHARACTERISTICS

• BS with 5+ years of relevant experience or an advanced degree with 3+ years of relevant academic or industry experience.

• Expertise in neurodegenerative and neuroinflammatory disease and experience with cell- and animal-based disease models.

• A track record of publications in neurodegenerative disease, neuroimmunology, immunology, and/or related areas.

• Extensive experience with both in vivo and in vitro models and tools preferred.

• Highly organized, collaborative, and effective working on teams.

• Understanding of in vivo pharmacology and/or molecule biodistribution in rodents or NHPs.

• Ability to work collaboratively to identify and execute key steps necessary to advance projects.

• Ability to effectively develop and discuss experimental goals and research progress with scientists and stakeholders of varied backgrounds.

• Excellent analytical and communication skills.

Why Choose Us?

• Bring the miracles of science to life alongside a supportive, future-focused team.

• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

#GD-SA ​
#LI-SA
#LI-Onsite
 #vhd 

All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.