Post Doctoral Fellow - Process Modelling

Job Title: Post Doctoral Fellow - Process Modelling

Location: Framingham, MA

About the Job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress.

As a Post Doctoral Fellow - Process Modelling, you will be based in the Global CMC Development group in Research & Development (R&D). You will work at the intersection of Data Science and Commercial Cell Culture Process Development to develop novel platform strategies for modelling, simulation, optimization and control of glycosylation within Sanofi’s cell culture processes.

With formal training in mammalian cell glycosylation and computational modelling, you will have demonstrated skills in the field of mechanistic, hybrid and/or data-driven modelling methodologies.  

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?

Main Responsibilities:

• Using historical data and expertise within the process development teams to identify key handles for the robust manipulation of glycosylation across Sanofi cell lines

• Using machine learning, mechanistic or hybrid modeling methodologies to develop a mathematical model in Python that describes the effect of these handles on glycosylation within the Sanofi platform across multiple strains and products

• As needed, run shake flask experiments with a library of Sanofi cell lines and recombinant products to obtain additional training data for media additives. Lab time to be minimal.

• Using this trained model, demonstrate a platform control strategy to adapt this model to a new cell line and product with minimal experimentation

• Advocate and implement this model-based control strategy within Sanofi

• Document progress against deliverables with scientific communication via technical presentations and reports to key stakeholders and partners across departments

• Present and publish findings in scientific conferences and peer-reviewed journals

About You

Basic Qualifications:

• Must have a PhD in Chemical Engineering, Biochemical Engineering, or Bioengineering

• Domain knowledge in mammalian cell glycosylation and computational modeling

• Demonstrated ability in computational modeling in MATLAB, Python, or R

• Must be able to relocate to the office location and work 40hrs/week, Monday-Friday, for the full duration of the PostDoc

• Track record of publications and conference presentations

• Excellent communication skills in an international environment

Preferred Qualifications:

• Prior publications in the field of glycosylation for mammalian cell culture, including computational/modeling approaches

• Prior experience with hybrid modeling methodologies

• Prior experience with computational optimization or model-based control

• Experimental experience in mammalian cell culture and glycan quantification

The salary for this position is ​$95,000 annually​. All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs. Additional benefits information can be found through LINK.​

Why Choose Us?

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.