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Manufacturing and Supply

Manufacturing and Supply
Where the
miracles of
science
are made
a reality
for patients

Head of SMS Program

Singapore, Singapore
Apply now

At a glance

Our teams produce and deliver over 4 billion units of medicines and vaccines every year, ensuring every breakthrough gets to the people who need it most.
Our state-of-the-art facilities, AI-powered smart factories, and cutting-edge automation are redefining what’s possible: ensuring treatments reach patients faster, safer, and more sustainably than ever before. This is where your skills, ambition, and passion can shape the future of healthcare.

About the Job

Sanofi Manufacturing and Supply organization is preparing its future through an ambitious program named Modulus. The Modulus Project is at the cornerstone of Sanofi's strategy, creating a new generation of evolutive, multi-product manufacturing facilities that are modular, adaptable and agile, leveraging disruptive technologies to better address vaccine and Specialty Care Biologics manufacturing needs.

As the Head of SMS Program, you will lead the deployment, governance and continuous evolution of the Sanofi Manufacturing System (SMS) across the site. You will be responsible for driving operational excellence, enabling sustainable performance improvements, embedding standardized operating practices, and strengthening continuous improvement capabilities while partnering closely with Site Leadership, Global SMS teams and cross-functional stakeholders.

As a Head of SMS Program, you will be:

Driving site performance and transformation

  • Lead the deployment and continuous evolution of the Sanofi Manufacturing System (SMS 2.0) across the site.
  • Drive performance transformation initiatives including SMS deployment, performance boosters, continuous improvement programs and Factory 4.0 solutions.
  • Identify operational performance gaps through benchmarking, maturity assessments and data-driven analysis, translating insights into improvement opportunities.
  • Ensure performance initiatives deliver measurable business impact across Quality, Delivery, Cost, Safety and People objectives.
  • Lead change management activities to embed sustainable operational excellence practices across the organization.

Ensuring impact and sustainability

  • Establish governance to monitor initiative Progress, benefits realization and long-term sustainability.
  • Drive value realization by partnering with Finance, Operations and Procurement to validate and capture savings generated through transformation initiatives.
  • Monitor performance indicators and proactively identify risks requiring corrective actions.
  • Ensure continuous improvement initiatives are standardized, sustained and replicated where applicable across the manufacturing organization.

Developing SMS operating standards and capabilities

  • Partner closely with Global SMS ecosystem leaders to develop, deploy and continuously improve SMS operating standards.
  • Support Manufacturing & Supply network initiatives including SMS Maturity Assessments, SMS Trainer activities and cross-site knowledge sharing.
  • Lead the site's SMS capability building strategy by developing structured upskilling roadmaps and continuous learning programs.
  • Foster a culture of operational excellence through coaching, mentoring and capability development at all organizational levels.


Leading governance and decision making

  • Manage resource allocation for performance and transformation initiatives.
  • Oversee the site digital budget supporting SMS deployment and Factory 4.0 initiatives.
  • Define execution approaches for operational excellence programs and transformation initiatives.
  • Establish expected value creation targets and confirm realization of business benefits.
  • Lead the development of the site's SMS capability roadmap.
  • Drive periodic reviews and annual upgrades of SMS operating standards in partnership with Global Manufacturing & Supply teams.

About You

Experience

  • Minimum 8 years of experience leading Operational Excellence, Lean, Six Sigma or Continuous Improvement programs within the pharmaceutical or other highly regulated manufacturing industries.
  • Proven experience leading enterprise transformation and change management initiatives.
  • Demonstrated experience deploying manufacturing operating systems and driving sustainable operational performance improvements.
  • Experience working within cGMP regulated manufacturing environments.

Technical & Functional Skills

  • Strong knowledge of Sanofi Manufacturing System (SMS) operating standards and SMS certification framework preferred.
  • Expertise in Operational Excellence methodologies including Lean Manufacturing, Six Sigma, Agile and Continuous Improvement.
  • Strong understanding of manufacturing financial performance including Profit & Loss, Gross Margin, Cost of Goods Sold (COGS), Business Operating Income (BOI), cash flow and project portfolio management.
  • Knowledge of performance management methodologies and tools including 3P and Shine.
  • Good understanding of data management and digital products supporting SMS operating standards, including eOEE, FaCT, iObeya and related digital manufacturing solutions.
  • Knowledge of Manufacturing 4.0 concepts including integrated manufacturing systems, MES, SAP, DeltaV, Historian, LIMS and paperless manufacturing.
  • Knowledge and practical application of AI and Generative AI solutions within manufacturing or operational excellence.
  • Strong project management, stakeholder management and communication skills.
  • Good understanding of cGMP requirements and pharmaceutical manufacturing processes.

Pursue Progress. Discover Extraordinary.

Join Sanofi and step into a new era of science - where your growth can be just as transformative as the work we do. We invest in you to reach further, think faster, and do what’s never-been-done-before. You’ll help push boundaries, challenge convention, and build smarter solutions that reach the communities we serve. Ready to chase the miracles of science and improve people’s lives? Let’s Pursue Progress and Discover Extraordinary – together.

At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, protected veteran status or other characteristics protected by law.

Watch 'One day at Sanofi' and check out our Diversity Equity and Inclusion initiatives at sanofi.com

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Why work with us

  • We’re problem-solvers and pioneers. United by the belief that everyone deserves a healthier future. We create best-in-class vaccines that prevent disease and protect lives.

  • Innovation drives us. From AI and mRNA to next-gen science, we push the boundaries to deliver first- and best-in-class vaccines for infectious diseases worldwide.

  • Growth happens here. With bold investments in R&D and world-class facilities, Sanofians across the entire vaccine lifecycle are shaping the future of global health.

  • We do what’s right. Sustainability and DE&I drive our positive global impact—because the diverse communities Sanofians represent are the patients we serve.

All-in on diversity

At Sanofi, diverse perspectives fuel the best solutions for patients. Hear from Monique Vessey, our Supply Chain Transformation Leader, on how her background shapes her approach to delivering life-changing medicines.

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"Manufacturing and Supply is the bridge between the science that happens in research laboratories and the people and communities we serve."

Brendan O’Callaghan

Executive Vice President of Manufacturing and Supply

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