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2025 Post Doctoral Fellow - Structural Biology and Protein Design

Cambridge, Massachusetts Fixed Term Posté le   Jul. 01, 2025 Expire le   Aug. 04, 2025
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Job Title: 2025 Post Doctoral Fellow - Structural Biology and Protein Design

Location: Cambridge, MA

About the Job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate Progress.

Our structure biology team embedded within the vibrant scientific environment of Large Molecules Research at Sanofi in Cambridge Crossing has an exciting postdoc opportunityfor a structure biologistto accelerate biologics discovery.The postdoc will work as a valued team member to apply the latest advances in structural biology and biophysics within our research portfolio while playing a role in Sanofi’s ongoing efforts to reinvent drug discovery.

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?

Main Responsibilities:

The successful candidate is a team player with excellent communication skills, has expertise in all aspects of cryoEM from sample preparation, data collection, data processing through 3D reconstruction. The candidate will advance a cryoEM-enabled ML workflow to develop rationalin silicobiologics discovery while contributing to Sanofi’s ambition to lead in structure-based computational approaches for biologics development.

About You

Basic Qualifications:

  • Must have a PhD in protein biochemistry, biophysics, structural biology, or related discipline by October 2025

  • Expertise in cryo-EM grid preparation, screening, and data collection

  • Experience in Linux terminal usage/shell-scripting and python scripting

  • Experience with Single particle EM data processing, three-dimensional structure determination, and model building

  • Structure biology and/or Cryo-EM research contributions demonstrated through authorship in peer-reviewed publication(s)

Preferred Qualifications:

  • Self-motivated, innovative, and able to handle multiple challenging projects in parallel

  • Excellent presentation skills to communicate structural biology findings, and enhance team-based progress

  • Ability to work independently, and effectively within timelines and collaborate in a highly multidisciplinary environment

  • Experience with protein purification, analytical and biophysical characterization

  • Experience in cloud computing and AI/ML applications in structural biology is a plus 

  • Experience with Protein engineering and in silico protein design

Why Choose Us?

  • Bring the miracles of science to life alongside a supportive, future-focused team.

  • Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

  • Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

  • Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

The salary for this position is ​$95,000 annually​. All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs. Additional benefits information can be found through LINK.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.

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