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Senior Principal Scientist I, Quantitative Pharmacology

Cambridge, Massachusetts Permanent Posté le   May. 23, 2025 Expire le   Aug. 29, 2025 Salary Range   USD 147,000.00 - 212,333.33
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Job Title: Senior Principal Scientist I, Quantitative Pharmacology

Location: Cambridge, MA

About the Job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate Progress.

Sanofi is seeking an experienced Quantitative Pharmacology (QP) project expert to join the Research QP Innovation Group within our Translational Medicine Unit (TMU).

As a member of the QP department, you will represent the Research QP Innovation Group on pre-clinical drug discovery projects, effectively integrating QP science into our strategy of developing first and best in class therapies for Immunology, Inflammation, Oncology, Rare and Neurological diseases.

As an integral project team member supporting early research, you will contribute to the translational strategies for novel modalities, innovative targeting approaches, QP technology applications and transversal scientific initiatives. You will support a breadth of projects, identifying opportunities across the organization to bridge and advance QP sciences with key partner lines to ultimately deliver QP strategic thinking towards the success of the emerging Sanofi portfolio.

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?

Main Responsibilities:

Responsibilities will include but are not limited to:

  • Characterize the ADME and PK properties for diverse modalities (primarily biotherapeutics)

  • Conceive and implement the preclinical PKPD strategy for a drug and/or target

  • Representing QP and the TMU on cross functional project teams as a project team leader

  • Conceive and implement the strategy towards predicting efficacious and safe human dose levels

  • Support the QP organization by addressing critical knowledge gaps

About You

Requirements and Qualifications

  • A Ph.D. in Pharmacokinetics or other relevant field + a minimum of 7 years relevant experience

  • The ability to function in a matrix and global environment  

  • Experience supporting NBE therapeutics

  • Ability to drive and lead PK, PKPD and ADME strategies for discovery project teams

  • Knowledge of and/or ability to conduct non-compartmental analysis (NCA) for non-GLP PK and TK reports

  • Experience with pharmacokinetics, pharmacometrics, PKPD relationships, bioanalytical techniques and/or ADME principles in a drug discovery setting

  • Willingness to grow and learn into role

  • Strong written, presentation and verbal communication skills are essential

  • Strong leadership and teamwork skills

Preferred Qualifications

  • Experience with protein engineering concepts

  • Experience with modeling & simulation concepts

Why Choose Us?

  • Bring the miracles of science to life alongside a supportive, future-focused team.

  • Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

  • Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

  • Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.

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