Senior Scientist - Medicinal Chemistry, Integrated Drug Discovery

Position Title

Senior Scientist - Medicinal Chemistry, Integrated Drug Discovery

Job overview

An accomplished synthetic organic and medicinal chemist, with a good track record of being a key project contributor, to design and synthesize small molecule targets.

Responsibilities

• Design and synthesize small molecule targets to drive programs to clinical candidate nomination.
• Use reaction and reagent databases to select effective techniques/routes to maximize productivity and provide solutions to complex multi-step synthetic problems.
• Prepare and characterize high purity target compounds and intermediates to meet aggressive project timelines.
• Proficient in the use of analytical techniques for structural characterization and able to interpret complex NMR spectra.
• Register compounds in corporate database and maintain notebooks according to SOP.
• Champion new chemistry techniques, reagents and methodology in discovery chemistry and participate in group/lab responsibilities.
• Fully understand SAR around own work and project, and able to prioritize work proactively based on emerging data.
• Interpret biological data (DMPK, pharmacology, safety) to identify issues.
• Using knowledge and work experience, work independently, proactively and collaborate with other team members to design target compounds which address issues.
• Ability to learn from the literature and meetings and make decisions that require developing new options to solve moderately complex problems and move projects forward.
• Understand and articulate the scientific rationale of the project to other scientists.
• Provide formal and informal mentoring within project team and junior staff members.
• Determine the relevance of patent search results and assess the patentability of new targets. Assist with filing patent applications by reviewing claims and providing experimental data.
• Actively participate in medicinal chemistry discussions communicating own science in a clear and precise manner and raising issues which positively influence the direction of lead series.
• Communicate and interact with other staff members in a professional and courteous manner.
• Operate in the lab in a safe and efficient manner according to HSE guidelines and adhere to all mandatory company compliance requirements.
• Adapt to changes and challenges in a productive and professional manner.
• Act as an ambassador for the department and attend appropriate meetings to increase knowledge and stay current with journal and patent literature.

Requirements & Qualifications

• Bachelor’s Degree with minimum 8 years of relevant research experience in an academic or biopharmaceutical setting OR Master’s Degree with minimum 5 years of relevant research experience in an academic or biopharmaceutical setting OR PhD with minimum 3 years of relevant research experience in an academic or biopharmaceutical setting.
• Deep knowledge of organic chemistry and a growing understanding of medicinal chemistry principles.

• Consistent record of publications, patents and external presentations and involvement in professional society.