Director, Portfolio Strategy and Evolution – Rare Diseases
Cambridge, Massachusetts Regular Posté le Sep. 23, 2025 Expire le Sep. 29, 2025 Salary Range USD 172,500.00 - 249,166.66Job Title: Director, Portfolio Strategy and Evolution – Rare Diseases
Location: Cambridge, MA
About the Job
The Director, Portfolio Strategy & Evolution (PS&E) reports to the Global Head of Portfolio Strategy & Evolution within the Specialty Care Rare Diseases Franchise. The Director, Portfolio Strategy & Evolution (PS&E) will support the Franchise’s future growth in contributing to the development the integrated Therapeutic Area Strategy (TAS) of Rare Diseases. He/she will be a core member of the Global Project Teams and provide Commercial leadership and strategic direction on pipeline products moving from pre-clinical stages through Proof of Concept and towards commercialization. He/she will also partner closely with Business Development and M&A teams and conduct commercial assessments of external opportunities. The position is based in Cambridge, MA unless otherwise agreed to by the Global Head of PS&E.
We are an innovative global healthcare company, committed to transforming the lives of people with immune challenges, rare diseases and blood disorders, cancers, and neurological disorders. From R&D to sales, our talented teams work together, revolutionizing treatment, continually improving products, understanding unmet needs, and connecting communities. We chase the miracles of science every single day, pursuing progress to make a real impact on millions of patients around the world.
Main Responsibilities:
Contribute to TA/DA strategy development and execution
Work closely with other PS&E team members and the TAS core team; liaise with R/D/C/M/BD partners, Corporate Strategy, R&D Strategy, TA Heads, GBLs and GPHs. Present ad-hoc strategic assessments and recommendations to Rare Diseases Leadership.
Contribute to the development and articulation of the Rare Diseases TAS by conducting strategic assessments and developing scenarios and recommendations.
Analyze disease landscapes, identify and characterize risks and opportunities, integrate cross-functional inputs and support decision-making.
Support the preparation of the TAS presentation
Advance early pipeline and guide drug development with Commercial leadership
As a Global Project Team core member, collaborate with R&D, Medical, regulatory, CMC, HEVA and MAxP and represent NPP/Commercial on the Global Project Teams
Develop early commercial strategy and provide global commercial leadership to guide and optimize the development of pre-POC pipeline products
Lead the development of Target Product Profiles (TPP) based on thorough understanding of market dynamics and targeted differentiation and positioning
Develop commercial positioning and business case/forecast
Support milestone and phase transition decisions by contributing to the preparation and delivering presentations to governance bodies (TARC, RWG, DWG, IDCC)
Support and execute external innovation strategy in alignment with TAS
Partner with the BD and M&A teams (including Search & Evaluation, Transaction, Finance, Legal, M&A). Present external opportunity assessments and recommendations to Rare Diseases Leadership.
Lead commercial assessments including forecasting of external Business Development and M&A opportunities
Provide commercial insights on external assets screening and participate in the BD process from external innovation to due diligence, valuation, negotiation and integration.
Support investment decisions by contributing to the preparation of presentations to governance bodies (TxC, Investment Committee, Acquisition Committee)
Deliver data-driven assessments and recommendations
Direct integrated market analysis and competitive intelligence investigations to identify current and future trends within key disease settings and across the therapy area.
Generate insights to ensure data-driven assessments and informed decisions
Translate key insights into clear, actionable strategies
Develop robust commercial assumptions and forecast /business cases for internal programs and external opportunities
About You
Bachelor’s Degree required; MBA, MS or PhD in life science preferred
7+ years of relevant biopharmaceutical industry and/or consulting experience
Experience in New Product Planning, Strategic Marketing; and in Rare Diseases and/or Gene Therapies is highly preferred
Experience in strategy, forecasting, financial valuation, market research, market access, business development or portfolio decision preferred; understanding of drug development, regulatory and access environment preferred
Strong scientific background, demonstrated ability to understand and translate clinical/scientific information and to engage credibly with internal and external stakeholders around scientific topics
Strong leadership, strategic thinking, planning, analytical, decision making and problem-solving skills
Demonstrated ability to work collaboratively in a matrixed environment with many cross-functional partners
Excellent interpersonal, oral and written communication skills, including ability to synthesize and deliver a clear overview of the strategy, opportunity and risks. Ability to prepare and deliver high quality presentations.
Demonstrated learning agility, driven and result-oriented; Ability to work on multiple projects simultaneously and effectively prioritize work with a sense of urgency
Ability to work in a fast-paced environment and quickly adjust to changing priorities
Valid passport and ability to travel internationally approximately 20% of the time
Why Choose Us?
Bring the miracles of science to life alongside a supportive, future-focused team.
Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.
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