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Distinguished Scientist, Systems Toxicology

Cambridge, Massachusetts Permanent Posted on   Oct. 29, 2024 Closing on   Apr. 10, 2025
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Job Title: Distinguished Scientist, Systems Toxicology

Location: Cambridge, MA

About the Job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress.

Sanofi has a deep commitment to supporting patient safety throughout the entire research and development process. Based on this principle, Preclinical Safety is seeking an experienced scientist with broad expertise in advanced approaches in network and pathway toxicology, applied toxicogenomics, and translational safety to support risk assessment of candidate molecules in our pipeline.

This role requires a deep understanding of toxicology, biological networks, and omics data. The successful candidate will lead efforts to apply this knowledge toward a deeper understanding of the molecular mechanisms underlying drug toxicity, working collaboratively with colleagues and subject matter experts across multidisciplinary teams. Further, the candidate will be responsible for developing and implementing innovative strategies for mechanistic toxicology assessment, providing expert guidance on related issues, interacting with the Digital Toxicology group at Sanofi, and ensuring compliance with regulatory guidelines and industry standards.

The successful candidate will have superior communication and networking skills that will enable successful integration of safety information and result in actionable outcomes that ultimately improve patient safety. Staying current with advancements in the toxicology field, mentoring junior scientists, and collaborating with cross-functional teams are also key to success in this role.

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?

Main Responsibilities

  • Conduct informatics-based risk assessment for potential or identified toxicity concerns to support the safety strategy for molecules in the research and development pipeline.

  • Analyze and interpret omics data in support of risk assessment or generation of mechanistic hypotheses.

  • Collaborate with preclinical and clinical project team members and subject matter experts to support project-specific safety requirements; facilitate learnings and application between projects where relevant.

  • Interface with the Digital Toxicology group at Sanofi to support quantitative systems toxicology modeling efforts and predictive safety model generation.

  • Facilitate and oversee investigative and strategic assay and model development/qualification efforts in collaboration with Global Investigative Toxicology colleagues.

  • Author white papers, reports, or components of regulatory submissions to support integration of risk assessment data as needed and provide subject matter expertise where applicable.

  • Participate in external consortia and symposia to keep current with industry trends and regulatory evolution in the systems toxicology field; represent Sanofi interests, maintaining high ethical and scientific standards.

  • Author external presentations and manuscripts to contribute to scientific advancement of the toxicology field.

About You

Requirements & Qualifications

  • PhD in Toxicology or equivalent scientific discipline required, with a minimum of 10+ years of experience in the pharmaceutical or biotechnology industry working in safety-relevant role(s).

  • Excellent data mining, analysis, integration, interrogation, and interpretation skills are essential, specifically with respect to ‘omics data, and application to toxicology is critical.

  • Strong knowledge of regulatory safety requirements in the field of pharmaceutical drug development is also necessary.

  • Natural strengths in networking and communication are also essential. Established record of scientific contribution in peer-reviewed journals and scientific symposiums should be evident.     

Travel

  • Occasional domestic and international travel to Sanofi Research and Development sites and scientific meetings. 

Why Choose Us?

  • Bring the miracles of science to life alongside a supportive, future-focused team.

  • Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

  • Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

  • Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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Pursue progress. Discover extraordinary.

Progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. You can be one of those people. Chasing change, embracing new ideas and exploring all the opportunities we have to offer. Let’s pursue progress. And let’s discover extraordinary together.

At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, or gender identity.

Watch 'One day at Sanofi' and check out our Diversity Equity and Inclusion initiatives at sanofi.com

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