Post Doctoral Fellow - Microbial Strain Engineering for Biopharmaceutical Application - all genders (limited for 2 years)
Frankfurt am Main, Germany Fixed Term Date posted Oct. 24, 2024About the job
Our Team:
At Sanofi, we chase the miracles of science to improve people’s lives. In the Global CMC department of R&D we develop industrial-scale production processes to bring our pipeline molecules to the patient. As part of the Microbial Platform in Frankfurt, we are developing cutting edge manufacturing processes for the next generation of microbial-derived biologics.
To support our Host Strain Engineering Team in Frankfurt, we are looking for a highly self-motivated, innovative molecular biologist with passion for microbial biotechnology and synthetic biology who is eager to bring research into application.
Main responsibilities:
- Work independently as a fully integrated member of a cross-functional, interdisciplinary, and international CMC development team
- Lead planning, design, execution of molecular biological experiments, strain engineering and process development
- Develop, optimize and implement new and existing state-of-the-art process-relevant and molecular biological methods, including CRISPR for E. coli genome editing
- Engineer new E. coli strains with fundamentally optimized physiology for heterologous protein production and industrial manufacturing processes
- Data analysis and data interpretation, presentation and reporting of results to international and interdisciplinary audience, including through publications and conferences
- Follow, review, and share the latest project-related innovations and technology breakthroughs in academia and industry
- Contribute to collaborations with academic institutions
About you
Experience:
- Ph.D. with experience in molecular biology, microbiology, biochemistry, and microbial expression systems
- Track record within the field of recombinant protein expression, synthetic biology, and strain engineering with strong focus on bacteria, especially Escherichia coli
Scientific Skills:
- Hands-on experience in molecular cloning, bacterial strain engineering, genome editing, and analytical characterization of microbial strains is essential
- Experience in DNA sequence design, cloning software (SnapGene, Benchling etc.) and modern molecular cloning techniques (Golden Gate, Gibson assembly, etc.)
- Experience with CRISPR technologies (ideally with focus on bacteria) is a strong plus
- Strong experience with microbial synthetic biology concepts and physiology, with a focus on bacteria, ideally E. coli, is required
- Experience with metabolic engineering in bacteria and bacterial glycobiology is a strong plus
- Experience with bacterial high-throughput screening is a plus
In your cover letter, please highlight your motivation to apply, and how your experience and skillset are connected to this position.
Soft Skills:
- Passionate about biotechnology and synthetic biology
- Able to drive a scientific project from idea to application, "Can Do”-Attitude
- Demonstrated ability/willingness to quickly learn and perform in new areas, implement new techniques and instrumentation
- Ability to plan and execute experiments independently, organized, rigorous and adaptative
- Elaborate, structured and accurate way of working
- Innovative mindset and entrepreneurial spirit
- Strong team player with analytical skills and interest to work in a highly interdisciplinary area
- Fluent in English, preferably good German skills
- Languages: German, English
Why choose us?
- Bring the miracles of science to life alongside a supportive, future-focused team.
- Benefit from a well-thought-out benefits package that rewards your contribution and commitment.
- Start your career at an attractive location in the center of Germany and experience our modern working environment and benefit from hybrid, flexible working time models.
Pursue progress, discover extraordinary
Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.
At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, or gender identity.
Watch our ALL IN video and check out our Diversity Equity and Inclusion actions at sanofi.com
#LI-Onsite
#MolecularCloning
#StrainEngineering
#CRISPR
#SyntheticBiology
#Biotechnology
Pursue progress. Discover extraordinary.
Progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. You can be one of those people. Chasing change, embracing new ideas and exploring all the opportunities we have to offer. Let’s pursue progress. And let’s discover extraordinary together.
At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, or gender identity.
Watch 'One day at Sanofi' and check out our Diversity Equity and Inclusion initiatives at sanofi.com
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