Winter - Spring 2025 Co-Op, Structural Biology, CAD - Vaccine

About the Job

We are an innovative global healthcare company that helps the world stay ahead of infectious diseases by delivering more than 500 million vaccine doses a year. Across different countries, our talented teams are exploring new technologies to protect people and promote healthy communities. We chase the miracles of science every single day, pursuing progress to make a real impact on millions of patients around the world.

*At this time, Sanofi will not sponsor a new applicant for employment authorization, or offer any immigration related support for this position (i.e. H1B, F-1 OPT, F-1 STEM OPT, F-1 CPT, J-1, TN, or another type of work authorization). **

Essential Duties and Responsibilities:

• The candidate is expected to learn how to use structural biology tools such cryo-EM and/or X-ray crystallography to elucidate antigen-antibody complex structures

• The candidate is expected to prepare negative staining EM samples and perform data collection and data analysis using cryoSparc or equivalent 

• The candidate will participate in the cryo-EM sample preparation & optimization, grid screening and data collection using cryogenic electron microscope (Glacios and Krios)

• The candidate will perform cryo-EM data processing using cryoSparc or equivalent and model building using Phenix, Coot and Isolde

• The work involves the interpretation of biochemical results of antigen-antibody complexes (ELISA, SPR, BLI etc)

• The work also involves the data analysis for protein quality (SEC, DSF, DSC etc)

• The candidate is expected to generate in-silico structural model using Alphafold or other protein modeling algorithms

• The candidate is expected to have a solution-focused, team-oriented mindset and will interact closely with other investigators in research and development of novel vaccine candidates 

• This is a hands-on, laboratory-based role in a highly collaborative research environment

• Role will require planning, designing, executing, interpreting, and presenting data in an effective and scientific manner

• Participate in scientific discussions focusing on current technology of structural biology

• Maintain detailed records and communicate progress and challenges, as necessary

• Perform timely electronic laboratory notebook entries, review and submission for completed experiments.

About you

Basic Qualifications:

• Currently pursuing a PhD in Molecular Biology, Biochemistry, Biophysics, Structural Biology, or closely related discipline

• Must have permanent US work authorization

• Must be able to relocate to our Waltham office location and complete the full duration on the Co-op 

• A background in structural biology is required

• Ability to independently design, plan and execute scientific studies, including operation and maintenance of relevant instruments and troubleshooting are required

• Strong interpersonal, communication, collaboration and problem-solving skills are needed

Preferred Qualifications:

• Experience with cryo-EM sample preparation and grid clipping is preferred 

• Experience with cryo-EM data processing and model building is preferred

• Deep knowledge and hands on experience with the biochemical and biophysical tools (SPR, BLI, DSF, SEC etc.) is preferred

• Advanced skill in structural viewing program such as Pymol and ChimeraX is preferred

• Familiarity with viral fusion protein and antibody biology is preferred

Why Choose Us?

• Bring the miracles of science to life alongside a supportive, future-focused team.

• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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