Post-Doc
Vitry-sur-Seine, France Fixed Term Posted on Mar. 27, 2025 Closing on Jun. 30, 2025Post-Doc Position in Sanofi / WIDGET consortium
Expert in Biology, Molecular Biology, NGS & Single Cells
Abstract:
As part of the WIDGeT consortium1 (23M€, 5 years), we are currently researching a Postdoctoral candidate with a strong background in molecular biology and NGS for single cell application.
Overview of the research project:
The WIDGeT consortium (Viral Vector Intelligent Design for Gene Therapy) aims to accelerate the development of gene therapies using viral vectors derived from adeno-associated viruses (AAV) for the treatment of age-related macular degeneration and hereditary podocytopathies (kidney diseases), leveraging the potential of artificial intelligence (AI). As part of this challenging consortium, our team proposed to develop a new technology to provide very sensitive information of AAV’s transgene expression at the single cell level. This technology is based on droplet microfluidic, DNA barcoded, scRT-PCR and NGS.
Responsibilities:
·Develop, design, and execute complex experiments and analyze data.
·Write (Lab Book) and Present (PowerPoint) research findings.
·Mentor and co-supervise engineer, technician and undergraduate students involved in the research project.
·Report and collaborate with other members of the consortium.
Qualifications :
·Ph.D. in biology or molecular biology
·Strong Experience in Single-cell RNA sequencing
·Strong background in molecular biology, NGS experiments and analysis.
·Background in single cells experiment (10x, flow cytometer...)
·Appetite for bench work & wet lab
·Appetite for challenging project
·Background in Bioinformatic
·Familiarity with statistical software (Prism, Spotfire, other…)
·Fluent in English
·Excellent written and verbal communication skills.
·Experience with Recombinant AAV is a plus.
·Knowledge in organoids/tissues preparation is a plus.
·Experience in screening is a plus.
·Background in Droplet microfluidic is optional.
The Project Team:
A dedicated team was created in 2024 to tackle this challenging project. The team is composed of one researcher, one engineer and one technician.
The Lab:
Our innovative Team (~8 people) is based in Vitry-Sur-Seine (Suburbs of Paris) at Sanofi R&D site. We have two laboratories (L1 & L2) dedicated to droplet microfluidic technology, with access to diverse technologies (ARIA Fusion (FACS), PCR, qPCR and NextSeq Illumina).
Duration & Salary:
18 months to 4 years
Language:
English / French (optional)
References:
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